Detailed Phenytoin dosage information for adults and children. Includes dosages for Seizures, Status Epilepticus and Seizure Prophylaxis During or Following Neurosurgery; plus renal, liver and dialysis adjustments. PHENYTOIN LOADING DOSE (continued) How to administer: Before and after the infusion of phenytoin the needle or the catheter must be flushed by an injection of Each injection or infusion of intravenous phenytoin should be preceded and followed by an injection of sterile saline through the same needle or catheter to avoid local venous irritation due to alkalinity of the solution. (See section 4.4). Gannaway WL, Wilding DC, Siepler JK, King JH, Lee-Ow A. The safety of administering phenytoin sodium by intermittent intravenous infusion was evaluated. Twenty-eight adult patients in a neurosurgical intensive-care unit were studied; most patients had head trauma. Ninety-three doses of phenytoin Preparations containing phenytoin sodium are not bioequivalent to those containing phenytoin base (such as Epanutin Infatabs ® and Epanutin ® suspension); 100 mg of phenytoin sodium is approximately equivalent in therapeutic effect to 92 mg phenytoin base. Treatment with Phenytoin Sodium Injection can be initiated either with a loading dose or an infusion: Loading Dose : A loading dose of parenteral Phenytoin Sodium Injection should be injected slowly, not exceeding 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients. To avoid local venous irritation, inject sterile sodium chloride 0.9% through the vein or catheter before and after each phenytoin infusion. Do not administer as a continuous infusion. Continuous ECG and blood pressure monitoring is essential during infusion. Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures and partial seizures , but not absence seizures. [2] WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH RAPID INFUSION. WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH RAPID INFUSION. The rate of intravenous Phenytoin Sodium Injection administration should not exceed 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients because of the risk of severe. Carducci B, Hedges JR, Beal JC, Levy RC, Martin M. We evaluated the efficacy of constant intravenous (IV) phenytoin infusion. Thirty-eight patients were evaluated prospectively for complications of continuous-infusion phenytoin loading. A total dose of 18 mg/kg was administered as a solution of 500.